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A missing hiker from Denver entered the Sonoran Desert searching for the Lost Dutchman Gold Mine — and was never seen again. The disappearance of Jesse Capen in Arizona's Superstition Mountains.

In May 2005, Natalee Holloway vanished on the last night of her senior class trip to Aruba. A mystery that captured international attention and broke a family's heart.

3 reasons to vanish and 8 ways to disappear. Where would you go — Mexico, maybe Vegas? A bit of fun on a very serious topic.

A woman found in the Tucson desert under mysterious circumstances. She was given the name Jane Doe. It took 30 years to discover her true identity.

Mayushi Bhagat traveled from Vadodara to Jersey City on an F-1 student visa to attend the NY Institute of Technology. Then she disappeared.

A hidden discovery inside a Houston home left investigators searching for answers in a case that raises more questions than it resolves.